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PDE5 destroys cGMP, so a PDE5 inhibitor drug stops that, to ensure the cGMP can do its job properly and help keep you up. Grapefruit can increase the risk of experiencing side effects with Cialis or Cialis Daily. We recommend you avoid eating grapefruit or drinking grapefruit juice while you're taking this medicine and for a few days after you finish taking it. Cialis and Cialis Together contain the same active ingredient, tadalafil, and are both effective for up to 36 hours in helping you get and maintain an erection for sex.

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